Senior RIKEN scientist involved in stem cell scandal commits suicide
TOKYO—Yoshiki Sasai, a noted stem cell scientist at the RIKEN Center for Developmental Biology (CDB) in Kobe, Japan, who co-authored two controversial and later retracted papers that reported a simple way of reprogramming mature cells, was confirmed dead this morning, an apparent suicide. Local media reported he was found hanging from a stairway railing in the RIKEN complex in Kobe. Sasai was rushed to a nearby hospital but efforts to revive him were unsuccessful. He reportedly left a suicide note, but it has not been made public.RIKEN posted a brief note in Japanese on its website confirming the death along with a statement expressing regret over the loss of an irreplaceable scientist from RIKEN President Ryoji Noyori.Sasai, 52, was a corresponding author on one of the papers and a co-author of the other. Together, they reported the discovery of a new phenomenon the researchers called stimulus-triggered acquisition of pluripotency (STAP). The papers, whose lead author was Haruko Obokata, also of RIKEN CDB, appeared online in Nature on 29 January. After months of mounting claims of problems and a finding of research misconduct by Obokata by a RIKEN committee, Nature retracted the studies on 2 July. The retraction notices cite duplicated and mixed-up images, mislabeling, faulty descriptions, and “inexplicable discrepancies in genetic background and transgene insertion sites between the donor mice and the reported” STAP cells.Sign up for our daily newsletterGet more great content like this delivered right to you!Country *AfghanistanAland IslandsAlbaniaAlgeriaAndorraAngolaAnguillaAntarcticaAntigua and BarbudaArgentinaArmeniaArubaAustraliaAustriaAzerbaijanBahamasBahrainBangladeshBarbadosBelarusBelgiumBelizeBeninBermudaBhutanBolivia, Plurinational State ofBonaire, Sint Eustatius and SabaBosnia and HerzegovinaBotswanaBouvet IslandBrazilBritish Indian Ocean TerritoryBrunei DarussalamBulgariaBurkina FasoBurundiCambodiaCameroonCanadaCape VerdeCayman IslandsCentral African RepublicChadChileChinaChristmas IslandCocos (Keeling) IslandsColombiaComorosCongoCongo, The Democratic Republic of theCook IslandsCosta RicaCote D’IvoireCroatiaCubaCuraçaoCyprusCzech RepublicDenmarkDjiboutiDominicaDominican RepublicEcuadorEgyptEl SalvadorEquatorial GuineaEritreaEstoniaEthiopiaFalkland Islands (Malvinas)Faroe IslandsFijiFinlandFranceFrench GuianaFrench PolynesiaFrench Southern TerritoriesGabonGambiaGeorgiaGermanyGhanaGibraltarGreeceGreenlandGrenadaGuadeloupeGuatemalaGuernseyGuineaGuinea-BissauGuyanaHaitiHeard Island and Mcdonald IslandsHoly See (Vatican City State)HondurasHong KongHungaryIcelandIndiaIndonesiaIran, Islamic Republic ofIraqIrelandIsle of ManIsraelItalyJamaicaJapanJerseyJordanKazakhstanKenyaKiribatiKorea, Democratic People’s Republic ofKorea, Republic ofKuwaitKyrgyzstanLao People’s Democratic RepublicLatviaLebanonLesothoLiberiaLibyan Arab JamahiriyaLiechtensteinLithuaniaLuxembourgMacaoMacedonia, The Former Yugoslav Republic ofMadagascarMalawiMalaysiaMaldivesMaliMaltaMartiniqueMauritaniaMauritiusMayotteMexicoMoldova, Republic ofMonacoMongoliaMontenegroMontserratMoroccoMozambiqueMyanmarNamibiaNauruNepalNetherlandsNew CaledoniaNew ZealandNicaraguaNigerNigeriaNiueNorfolk IslandNorwayOmanPakistanPalestinianPanamaPapua New GuineaParaguayPeruPhilippinesPitcairnPolandPortugalQatarReunionRomaniaRussian FederationRWANDASaint Barthélemy Saint Helena, Ascension and Tristan da CunhaSaint Kitts and NevisSaint LuciaSaint Martin (French part)Saint Pierre and MiquelonSaint Vincent and the GrenadinesSamoaSan MarinoSao Tome and PrincipeSaudi ArabiaSenegalSerbiaSeychellesSierra LeoneSingaporeSint Maarten (Dutch part)SlovakiaSloveniaSolomon IslandsSomaliaSouth AfricaSouth Georgia and the South Sandwich IslandsSouth SudanSpainSri LankaSudanSurinameSvalbard and Jan MayenSwazilandSwedenSwitzerlandSyrian Arab RepublicTaiwanTajikistanTanzania, United Republic ofThailandTimor-LesteTogoTokelauTongaTrinidad and TobagoTunisiaTurkeyTurkmenistanTurks and Caicos IslandsTuvaluUgandaUkraineUnited Arab EmiratesUnited KingdomUnited StatesUruguayUzbekistanVanuatuVenezuela, Bolivarian Republic ofVietnamVirgin Islands, BritishWallis and FutunaWestern SaharaYemenZambiaZimbabweI also wish to receive emails from AAAS/Science and Science advertisers, including information on products, services and special offers which may include but are not limited to news, careers information & upcoming events.Required fields are included by an asterisk(*)To date, no other groups have succeeded in reproducing the work. RIKEN has a team attempting to determine what went wrong and conclusively determine if the STAP phenomenon is real. A separate committee has been charged with determining disciplinary measures for Obokata and her RIKEN co-authors and supervisors, including Sasai, although decisions have been put off pending the results of the ongoing investigation.A prolific developmental biologist, Sasai had risen to be deputy director of the center and was considered a contender to become its director. He was credited with helping recruit Obokata. Adding his name to her papers gave them credibility because of his reputation and standing in the community. Researchers were shocked and saddened by the news. “So very very sad! My sincere sympathy to Sasai’s family. Community lost a great developmental biologist!” Kenneth Lee, a stem cell researcher at the Chinese University of Hong Kong, tweeted shortly after the news broke. “This is a tragedy and thoughts go out to his family, friends, and lab members,” wrote stem cell researcher Paul Knoepfler, of the University of California, Davis, School of Medicine in Sacramento, on his blog.